When you inhale e-cigarette smoke, some components of the liquid enter your lungs. According to research, about 70-80% of smoke particles will stay in the lungs, while the remainder will be exhaled. Although most substances are eventually absorbed and metabolized by the body, smoking for a long time may cause certain components, such as heavy metals and certain harmful chemicals, to accumulate in the lungs.

Introduction to the ingredients of e-cigarette liquid
Propylene Glycol and Glycerin
Propylene glycol, also known as propylene glycol, is one of the main ingredients in e-cigarette liquids. It is often used as a stabilizer or thickener in foods, cosmetics and pharmaceuticals. The power of propylene glycol in e-cigarettes is generally 40-60%. Glycerin, or sucitol, is another major e-cigarette liquid ingredient, and its power typically accounts for 20-40% of the total volume of the liquid. Glycerin is mainly used to create large amounts of smoke and provide smokers with a satisfying taste. In terms of cost, these two ingredients are relatively low, with an average cost of about $10-$20 per kilogram.
nicotine
Nicotine is a harmful ingredient in e-cigarette liquids, which is extracted from tobacco. Nicotine is added to satisfy smokers' addiction. The nicotine power usually ranges from 0.1% to 5%, depending on the brand and specifications of the e-cigarette. A typical 30ml e-liquid bottle may contain 0mg to 50mg of nicotine, with a value of approximately $0.5-$3. Nicotine is considered a highly addictive substance and excessive intake can cause harm to the body.
Flavors and other additives
Various flavors are also added to e-cigarette liquids to provide different flavor options, such as fruity, dessert, or tobacco. The power of these fragrance ingredients usually ranges from 5% to 15%. In addition, other chemicals may be added to e-cigarette oil, such as caffeine, pigments, etc., but their total power does not exceed 2%. The specific specifications and parameters of these additives vary by brand and type, and the price is generally in the range of $1-$5.
Comparison of e-cigarettes and traditional cigarettes
smoke components
There are big differences in the composition of smoke between e-cigarettes and traditional cigarettes. Traditional cigarettes release more than 7,000 chemicals when burned, many of which are known carcinogens, such as benzene and formaldehyde. E-cigarettes do not involve a combustion process. They turn liquid into vapor through electrical heating, thereby reducing the release of a large number of harmful substances. However, it should be noted that e-cigarette smoke still contains some harmful substances, such as formaldehyde and acetaldehyde, but in lower concentrations.
Inhalation method
Traditional cigarettes need to be lit with a lighter, while e-cigarettes require charging and battery power. The size and shape of traditional cigarettes are relatively standard, usually about 85-100mm in length and 8-9mm in diameter. The sizes and specifications of electronic cigarettes are more diverse, ranging from pen type to box type, with sizes ranging from 90mm to 200mm. In terms of cost, the average price of traditional cigarettes is $5-$15/pack, while the initial investment cost of e-cigarettes is $30-$100, but its subsequent costs are lower, about $5-$20 per bottle of liquid.
effects on lungs
Both e-cigarettes and traditional cigarettes have certain effects on the lungs. Tar, nicotine and other harmful substances in traditional cigarettes have been proven to be harmful to the lungs and can lead to lung cancer, chronic bronchitis and other respiratory diseases. Relatively speaking, e-cigarettes may be less harmful to the lungs, but there are still risks. Studies have shown that certain chemicals in e-cigarette smoke may cause lung inflammation or other problems. However, research into the long-term effects of e-cigarettes on the lungs is still ongoing, and their safety cannot yet be determined.
How e-cigarette liquids behave in the lungs
Distribution after inhalation
When e-cigarette smoke is inhaled, the liquid first enters the mouth and then enters the respiratory tract and lungs. Since the particle size of e-cigarette smoke is approximately 0.1-1 micron, they can penetrate deep into the small airways and alveoli of the lungs. According to some studies, about 70-80% of smoke particles stay in the lungs, while the remaining 20-30% are exhaled.
Absorption and metabolism of e-cigarette liquid
The main ingredients in e-cigarette liquids, such as nicotine, propylene glycol and glycerin, are quickly absorbed into the lungs after inhalation. For example, nicotine reaches the brain in about 10 seconds after being inhaled. In the body, nicotine has a half-life of approximately 1-2 hours, with most nicotine metabolized by the liver and ultimately excreted in the urine. At the same time, propylene glycol and glycerol are mainly metabolized in the lungs, liver and kidneys and excreted in the form of carbon dioxide and water.
Cumulative effects of long-term smoking
Prolonged use of e-cigarettes may cause their ingredients to accumulate in the lungs. For example, certain heavy metals and harmful chemicals, such as cadmium, lead, and formaldehyde, can lodge in lung tissue and cause permanent damage. In addition, long-term smoking may lead to alveolar inflammation, airway hypersensitivity to smoke, and reduced lung function. Long-term vaping may increase the risk of chronic bronchitis, asthma and other respiratory diseases, according to some preliminary research.
Related research and experimental results
Experimental Study
The effects of e-cigarettes have been the focus of many laboratory studies. In some studies, many potentially harmful substances, such as formaldehyde, acetaldehyde and some heavy metals, have been found by analyzing the components in e-cigarette vapor. For example, a study conducted at Harvard University showed that 52% of e-cigarette samples contained dioxins, which are harmful to humans. In addition, certain flavoring ingredients in e-cigarette liquids have also been found to cause lung diseases such as "popcorn lung."
Clinical Observation
Clinical observational studies mainly focus on the direct effects of e-cigarettes on human health. Some clinical observations indicate that e-cigarette users may experience difficulty breathing, dry cough, and sore throat. According to the World Health Organization, nicotine intake exceeding 50mg may be harmful to adults, and the nicotine content in each bottle of e-cigarette liquid can be as high as 59mg.
long term effects
Although e-cigarette use has a relatively short history, there are already some preliminary long-term studies suggesting potential health risks. For example, long-term e-cigarette users may experience airway inflammation, reduced lung function, and decreased oxygenation capacity. Other studies have found that e-cigarettes may increase the risk of cardiovascular disease, lung cancer and respiratory disease, although these risks are still lower than traditional cigarettes.
Potential lung health risks of e-cigarettes
E-cigarette liquids and lung disease
E-cigarette liquids contain many chemical ingredients, some of which have been shown to be harmful to the lungs. For example, a chemical called diacetyl has been linked to a rare lung disease called popcorn lung. In addition, harmful substances such as formaldehyde and acetaldehyde in e-cigarette vapor have also been linked to lung damage. In addition, e-cigarette vapor may cause oxidative stress on lung cells, leading to cell damage and inflammation. According to the American Lung Association, e-cigarette users experience a 20% increase in airway resistance, likely due to inflammation and cell damage in the lungs.
E-cigarettes and respiratory infections
E-cigarettes may increase the risk of respiratory infections. Some studies have found that e-cigarette vapor can weaken the immune response in the lungs, making e-cigarette users more susceptible to influenza, pneumonia and other respiratory infections. In addition, nicotine may impair the function of cilia in the lungs, a mechanism that helps clear pollutants from the respiratory tract, thereby increasing the risk of infection.
Other long-term health risks
Long-term e-cigarette use may pose other health risks. The link between e-cigarettes and conditions such as cardiovascular disease, hypertension and diabetes is also being studied. In addition, although the concentration of nicotine in e-cigarettes is low, long-term inhalation may lead to nicotine dependence. According to the World Health Organization, smoking e-cigarettes for a long time may damage DNA, thereby increasing the risk of cancer.

